Sterling fell in European trade away from three-week highs against dollar, on track for the first loss in four days on profit-taking.
GBP/USD fell 0.1% to 1.2530, after closing up 0.4% yesterday, marking three-week highs at 1.2592.
UK Prime Minister Boris Johnson asserted his commitment to reach a trade deal with the EU before the Brexit transition ends on December 31.
The dollar index slipped 0.1% on Wednesday to near two-week lows against a basket of main rivals.
Investors are still clinging to hopes of quick recovery from Covid 19 pandemic even as cases continue to spike in the US, India, and Brazil, in turn hurting haven demand on the greenback.