Sterling tilted lower in American trade to late October lows against the dollar, following a spate of data from Britain and the US on Monday.
As of 06:43 GMT, GBP/USD shed 0.13% to 1.2733, with a session-high at 1.2825, and a five-week low at 1.2699.
Earlier UK data showed the manufacturing PMI rose to 53.1 from 51.1, beating estimates of 51.6.
UK Prime Minister Theresa May ruled out conducting another public referendum on Brexit, asserting all focus right now is on the Parliamentary vote on December 11.
Federal Reserve Governor Richard Clarida was interviewed today by Bloomberg TV & Radio, while Federal Reserve Governor Randal Quarles spoke about the economic outlook and monetary policy at the Council on Foreign Relations, in New York.
Earlier US data showed the final Markit Manufacturing PMI down to 55.3 in November from the flash trading of 55.4, and down from 55.4 in October.
The US ISM manufacturing PMI rose to 59.3 in November from 57.7, beating estimates of 57.5.
ISM manufacturing prices tumbled to 60.7 from 71.6, missing estimates of 70.1.
Construction spending fell 0.1%, same as September and missing estimates of a 0.4% increase.