Asian stock indices opened the second session of the week lower in tandem with Wall Street on mounting concerns over the second coronavirus wave, while hopes for a US stimulus package before the November elections fade.
UK-EU talks continue in an attempt to reach a trade deal in a few weeks before the final Brexit.
The US reported a new record Covid 19 daily infection rate, with Vice President Mike Pence reporting a positive Covid result.
The World Health Organization reported 42.97 million global coronavirus cases so far, with the death toll standing at 1.152 million.
Japan's TOPEX fell 0.41%, while Nikkei 225 declined 0.28% to 23,428.
China's CSI 300 declined 0.19% to 4,682, while Shanghai shed 0.26% to 3,242.
Hong Kong's Hang Seng fell 1.09%, while South Korea's KOSPI inched down 0.04% to 2,342.
New Zealand's NZX 50 dropped 1.39%, while Australia's S&P/ASX 200 gave up 1.85% to 6,041.