US stock indices opened the fourth session of the week lower, following a spate of data from the US, the world's largest economy, which showed unemployment claims fell past expectations, while the Philly manufacturing index slowed down in August to 18.9 from 19.5, besting expectations of 18.3.
Industrial production slowed down more than expected last month, while the Capacity Utilization Rate steadied in line with expectations.
Yesterday, US president Trump dissolved several business and manufacturing advisory counsels, forcing back business concerns about Trump's agenda, while the Federal Reserve's minute for the July 25-26 meeting showed policymakers' concerns about the recent softening inflation, despite asserting earlier this year the plan to normalize the bank's massive balance sheet.
As of 04:50 GMT, Standard and Poor's 500 fell 0.66%, or 16.45 points to 2,451.72, while Dow Jones tumbled 0.57%, or 125.18 points to 21,899.69.
Tech-heavy NASDAQ shed 0.85%, or 54.31 points to 6,290.82.